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Clinical and Vaccine Trials for COVID-19: Key Considerations from Social Science

Previous months have witnessed a growth of clinical research in response to the COVID19 crisis. This brief sets out social science considerations that can inform clinical and vaccine trials for COVID-19. It was developed for SSHAP by London School of Hygiene and Tropical Medicine (LSHTM) by Rose Burns, Alex Bowmer, Luisa Enria, Samantha Vanderslott (University […]

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Health-Seeking Behaviours in Sofala and Manica in Relation to Cyclone Idai Response

Rapid review question: What are the health-seeking and nutritional practices of the affected populations? How do they frame, understand and engage in prevention of cholera/AWD, malaria, measles/rubella (or vaccine preventable diseases); infant and child feeding and other relevant diseases? What do these entail in terms of behaviour change communication and community engagement? This review is […]

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Les Considérations Sociaux‐Culturelles pour l’introduction du Vaccin et l’Engagement Communautaire

Ce dossier résume les problèmes sociaux-culturels clés, liés à l’introduction du vaccin (sVSV-­ZEBOV) en RDC concernant la flambée épidémique d’Ébola en mai 2018. Nous devrions en parler davantage, mais étant donné l’introduction imminente du vaccin, la priorité a été accordée à la transmission des considérations clés et des recommandations immédiates, en particulier pour l’engagement communautaire. […]

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“We are the heroes because we are ready to die for this country”: Participants’ Decision-Making and “Grounded Ethics” in an Ebola Vaccine Clinical Trial

The 2014–2016 Ebola epidemic presented a challenging setting in which to carry out clinical trials. This paper reports findings from social science research carried out in Kambia, Northern Sierra Leone during first year of an Ebola vaccine trial (August 2015–July 2016). The social science team collected data through ethnographic observation, 42 in depth interviews; 4 […]

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Controversial Ebola Vaccine Trials in Ghana: A Thematic Analysis of Critiques and Rebuttals in Digital News

Communication is of paramount importance in responding to health crises. The authors studied the media messages put forth by different stakeholders in two Ebola vaccine trials that became controversial in Ghana. These interactions between health authorities, political actors, and public citizens can offer key lessons for future research. Through an analysis of online media, the […]

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Implementation of an Ebola Virus Disease Vaccine Clinical Trial during the Ebola Epidemic in Liberia: Design, Procedures, and Challenge

The index case of the Ebola virus disease epidemic in West Africa is believed to have originated in Guinea. By June 2014, Guinea, Liberia, and Sierra Leone were in the midst of a full-blown and complex global health emergency. The devastating effects of this Ebola epidemic in West Africa put the global health response in […]

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Power, Fairness and Trust: Understanding and Engaging with Vaccine Trial Participants and Communities in the Setting Up the EBOVAC-Salone Vaccine Trial in Sierra Leone

This paper discusses the establishment of a clinical trial of an Ebola vaccine candidate in Kambia District, Northern Sierra Leone during the epidemic, and analyses the role of social science research in ensuring that lessons from the socio-political context, the recent experience of the Ebola outbreak, and learning from previous clinical trials were incorporated in […]

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Beating the Odds: Successful Establishment of a Phase II/III Clinical Research Trial in Resource-Poor Liberia during the Largest-Ever Ebola Outbreak

It has been argued that a country such as Liberia, not fully recovered from the devastation of decades of civil unrest, lacked the appropriate ethical and regulatory framework, basic human and health care services, and infrastructure to carry out clinical trials according to international standards of quality during a public health emergency. However, as Liberia, […]

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Socio-Cultural Considerations for Vaccine Introduction and Community Engagement

This brief summarises key socio-cultural issues related to the introduction  of vaccine (rVSV-ZEBOV) to the DRC in relation to the Ebola outbreak, May 2018. A deeper dive should be undertaken, but given the imminent introduction of the vaccine, conveying key considerations and immediate recommendations, particularly for community engagement, has been prioritised. Informal discussions have been […]

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