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“We are the heroes because we are ready to die for this country”: Participants’ Decision-Making and “Grounded Ethics” in an Ebola Vaccine Clinical Trial

The 2014–2016 Ebola epidemic presented a challenging setting in which to carry out clinical trials. This paper reports findings from social science research carried out in Kambia, Northern Sierra Leone during first year of an Ebola vaccine trial (August 2015–July 2016). The social science team collected data through ethnographic observation, 42 in depth interviews; 4 […]

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Controversial Ebola Vaccine Trials in Ghana: A Thematic Analysis of Critiques and Rebuttals in Digital News

Communication is of paramount importance in responding to health crises. The authors studied the media messages put forth by different stakeholders in two Ebola vaccine trials that became controversial in Ghana. These interactions between health authorities, political actors, and public citizens can offer key lessons for future research. Through an analysis of online media, the […]

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Implementation of an Ebola Virus Disease Vaccine Clinical Trial during the Ebola Epidemic in Liberia: Design, Procedures, and Challenge

The index case of the Ebola virus disease epidemic in West Africa is believed to have originated in Guinea. By June 2014, Guinea, Liberia, and Sierra Leone were in the midst of a full-blown and complex global health emergency. The devastating effects of this Ebola epidemic in West Africa put the global health response in […]

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Ethical Considerations in the Conduct of Research on Therapies for the Prevention and Treatment of Ebola Virus Disease in Developing Countries

The devastating toll of the Ebola epidemic in West Africa necessitates considerations of new approaches to research into new prevention technologies and treatments for Ebola Virus Disease (EVD). Research must be planned and delivered in consultation with civil society from the epicentre to prevent mistrust and misunderstanding. Ethical considerations include development of local research and […]

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Power, Fairness and Trust: Understanding and Engaging with Vaccine Trial Participants and Communities in the Setting Up the EBOVAC-Salone Vaccine Trial in Sierra Leone

This paper discusses the establishment of a clinical trial of an Ebola vaccine candidate in Kambia District, Northern Sierra Leone during the epidemic, and analyses the role of social science research in ensuring that lessons from the socio-political context, the recent experience of the Ebola outbreak, and learning from previous clinical trials were incorporated in […]

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Community Perception and Beliefs About Blood Draw for Clinical Research in Ghana

Clinical research participants often express concerns about blood draw because of misconceptions about the uses to which the blood will be put. Their comments can generate rumours in their communities, thereby affecting rates of recruitment to research studies and increasing losses to follow-up. This study sought to identify community perceptions about blood draw for clinical […]

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