Community-led total sanitation (CLTS) is a widely applied rural behavior change approach for ending open defecation. However, evidence of its impact is unclear. UNC (Vidya Venkataramanan, Jonny Crocker, Andrew Karon, and Jamie Bartram) conducted a systematic review of journal-published and gray literature to assess evidence quality, summarize CLTS impacts, and identify factors affecting implementation and effectiveness which was published in Environmental Health Perspectives DOI:10.1289/EHP1965